In vitro interaction of aminoglycosides with beta-lactam penicillins

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In vitro interaction of aminoglycosides with beta-lactam penicillins.

The aminoglycosides are used clinically in combination with beta-lactam antibiotics. The combined use, however, produces an interaction and inactivation of the antibiotics. A study was designed to investigate the kinetics of the interaction in vitro. Four concentrations of aminoglycosides (5 to 20 micrograms of gentamicin and tobramycin per ml) and penicillins (100 to 600 micrograms of carbenic...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1985

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.28.2.274